Original research article
Porto Biomed. J. 2016; 1(5-5): 186-190 doi: http://dx.doi.org/doi:10.1016/j.pbj.2016.10.003 (Published 9 November 2016)

The acute effect of the antioxidant drug “U-74389G” on mean platelet volume levels during hypoxia reoxygenation injury in rats

C. Tsomposa, *, C. Panoulisb, K. Toutouzasc, A. Triantafylloud, G. Zografos, A. Papaloise

Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
Department of Biologic Chemistry, Athens University, Attiki, Greece
Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece
*Corresponding author:
Accepted 6 October 2016
abstract
Background: This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels. Methods: 40 rats of mean weight 231.875 g were used in the study. MPV levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D. Results: U-74389G administration kept significantly increased the predicted MPV levels by 12.77 ± 3.07% (p = 0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55 ± 3.71% (p = 0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09 ± 1.91% (p = 0.0005). Conclusions: U-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology.
keywords
Hypoxia; U-74389G; Reoxygenation; Mean platelets volume
We use cookies on this site to enhance your user experience. By clicking any link on this page you are giving your consent for us to set cookies.